Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)

The objective of this study is to investigate S.hermanni's antimalarial action against PfHT1 utilizing an in silico technique. In method, developing a protein target database by searching and collecting the structures from Protein Data Bank (PDB) UNIPROT databases. (PDB ID 6m20) with glucose control. Download all ligand PubChem database. Molecular docking analysis Molegro virtual docker predicts interactions between ligands targets. last step was visualization display 3D views their discovery studio program. control compound beta-D-glucopyranose binds at active site GLN169, GLN305, ASN341, GLY408, ASN311, GLN305. All compounds S.hermanni were able bind PfHT1. This indicates that enter cell via hexose transporter 1 (PfHT1) receptors, such as glucose. substances have antimalaria activity through PfHT1inhibition. Almost used similar binding sites, but only quinoxaline different sites. substance has variety affinities